Chemistry Faculty

Dr. Ajish K. R.

Education: BSc., MG University, 2003
MSc., MG University, 2006
B.Ed., MG University, 2007
Ph.D., CSIR-NIIST Thiruvananthapuram, 2015

Area of Specialization: Chemistry of Natural Products (Phytochemistry) Synthetic Organic chemistry Carbohydrate Chemistry

Phone:

Email:

Awards & Recognition:

Best Paper Award at 24t h Swadeshi Science Congress (SSC-2014), Thunjath Ezhuthachan

Malayalam University, Tirur, Malappuram, 2014.

 Best Paper Award at National Conference on Recent Advances in Spectroscopy, M. A. College,

Kothamangalam, 2014.

 Best Paper Award at 23 rd Swadeshi Science Congress (SSC-2013), M. G. University, Kottayam,

2013.

Best Paper Award at International Seminar on “Molecular Secrets of Plant Medicines (MSPM

2013) CMS College, Kottayam, 2013.

 Best Paper Award at National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013),

University of Kerala, Kariavattom, 2013.

 II nd rank, MSc Applied Chemistry, M.G. University, 2004-2006.

My major research areas are

Isolation, characterization and synthetic modifications of Phytochemical from various

medicinal plants found in Kerala and their biological evolution

 Transition metal catalyst mediated synthesis of bioactive molecules

Design, synthesis and biological evaluation of glycohybrids

CH1CO1 Organometallics and Nuclear Chemistry

AP3C09 Advanced Synthetic Organic Chemistry

AP3C11 Essential Oils and Aromatics

I. Articles in Peer Reviewed Journals

1. Studies on ?-glucosidase, aldose reductase and glycation inhibitory properties of

sesquiterpenes and flavonoids of Zingiber zerumbet Smith. K. R. Ajish, K. A. Antu, M. P.

Riya, M. R. Preetharani, K. G. Raghu, B. P. Dhanya K. V. Radhakrishnan, Natural Product

Research, 2015, 29, 947-952.

2. Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed

decarboxylative coupling reaction: A new class of ?-glucosidase inhibitors. K. R. Ajish,

B.P. Dhanya, Nayana Joseph, M. Priya Rani, K. G. Raghu, V. P.Vineetha and K. V.

Radhakrishnan. Tetrahedron lett. 2014, 55, 665-670.

3. Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with

potent glycation and a-glucosidase inhibition activities. K. R. Ajish, Nayana Joseph, M.

Priya Rani, K. G. Raghu, V. P. Vineetha, K. V. Radhakrishnan. Tetrahedron lett. 2013, 54,

5682-5685.

4. Transition-metal- catalyzed regio- and diastereoselective 1,4-conjugate addition of

zerumbone using boronic acids: A simple route toward novel zerumbone derivatives. K. R.

Ajish, Nayana Joseph, K. V. Radhakrishnan Synthesis 2013, 45, 2316-2322

II. Conferences

Oral presentations:

1. Synthesis and Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation

and ?-Glucosidase Inhibition Activities, Ajish K. R. and K. V. Radhakrishnan,24 th Swadeshi Science

Congress (SSC-2014), Thunchath Ezhuthachan Malayalam University, Malappuram, November,

2014 [Best Paper Award].

2. Isolation, Synthetic Transformation and Evaluation of Bioactives from Zingiber Zerumbet K.R.

Ajish, K. V. Radhakrishnan. National Conference on Recent Advances in Spectroscopy, M. A.

College, Kothamangalam, July 2014 [Best Paper Award].

3. Value addition to traditional knowledge: isolation, synthetic trasformation and evaluation of

bioactives from zingiber zerumbet (malayinji). K.R. Ajish, K. V. Radhakrishnan. 26 th Kerala Science

Congress, KVASU, Wayanad, January, 2014.

4. Synthesis of carbohydrate appended hydrazinocyclopentenes with potent glycation and ?-glucosidase

inhibition activities. K. R. Ajish, M. Priya Rani, V. P. Vineetha, K. G. Raghu, K. V. Radhakrishnan.

National Seminar on Current Trends in Chemistry (CTriC 2014), Department of Applied Chemistry,

Cochin University of Science and Technology (CUSAT), January, 2014.

5. Isolation, synthetic trasformation and biological evaluation of phytochemicals from zingiber

zerumbet smith (malayinji). K. R. Ajish, K.V. Radhakrishnan. 23 rd Swadeshi Science Congress

(SSC-2013), M. G. University, Kottayam, November, 2013 [Best Paper Award].

6. Value Addition to herbal plants: Synthetic transformation & biological evaluation of phytochemical

from Zingiber Zerumbet. K. R. Ajish, K.V. Radhakrishnan. International Seminar on “Molecular

Secrets of Plant Medicines (MSPM 2013) CMS College, Kottayam, October, 2013 [Best Paper

Award].

7. Isolation, characterization and biological evaluation of phytochemicals from the rhizomes of

Zingiber zerumbet Smith, Ajish K. R, M. Priya Rani, K. G. Raghu and K. V. Radhakrishnan, an oral

presentation at National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013), held at

University of Kerala, Kariavattom, may, 2013 [Best Paper Award].

Posters Presented:

8. Synthesis of novel zerumbone derivatives via transition metal catalyzed regio- and

diastereoselective 1,4-conjugate addition using boronic acids. K. R. Ajish, K. V.

Radhakrishnan. 9 th Junior National Organic Symposium Trust (J-NOST) Conference, IISER,

Bhopal, December, 2013.

9. Transition metal catalyzed regio- and stereoselective 1,4-conjugate addition of boronic acids

to zerumbone: A facile route towards novel zerumbone derivatives. K. R. Ajish, B. P.

Dhanya, K. V. Radhakrishnan. National Seminar on Emerging Trends in Chemical Sciences

(ETCS-2013), University of Kerala, Kariavattom, May, 2013.

10. Design and Synthesis of carbohydrate appended hydrazino cyclopentenes with triazole linker: A new

class of neoglycoconjugates with anti-glycation properties. K. R. Ajish, M. Priya Rani, K. G. Raghu,

K. V. Radhakrishnan. National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013),

University of Kerala, Kariavattom, May, 2013.

11. An efficient strategy to functionalized cyclopentenes via palladium catalyzed ring opening of

bicyclic hydrazines with catechol and resorcinol. K. R. Ajish, S. Saranya, K. Ramesh Babu, K. V.

Radhakrishnan. International Symposium on Drug Development for Orphan/Neglected Diseases

(CTDDR 2013), CDRI, Lucknow, February, 2013.

12. Efforts towards the Synthesis and Lanthanide Binding Studies of mannose Based

Neoglycoconjugates. K. R. Ajish, V. S. Sajisha, K. V. Radhakrishnan. National Conference

on Recent Trends in Organic Synthesis (RTOS 2011), Bharathidasan University,

Tiruchirappalli, February, 2011.