Syllabus

Module Course Description Hrs CO. No.
1.0 HISTORY OF CYTOLOGY AND INTRODUCTION TO CELL ORGANELLES 12  
1.1 Historical account of cell biology; cell theory and protoplasm theory 1 1
1.2 Prokaryotic and Eukaryotic cell 1 2
1.3 Cell: physio -chemical nature of plasma membrane and cytoplasm 1 1
1.4 Structural organization and function of intracellular organelles – cell wall 1 1
1.5 Nucleus 1 1
1.6 Mitochondria 1 1
1.7 Ribosomes, Dictyosomes 1 1
1.8 Microbodies, peroxisome  1  1
1.9 Golgibodies, lysosomes 1 1
1.10 Plastids, chloroplast 1 1
1.11 Endoplasmic reticulum, vacuoles 1 1
1.12 Structure and function of cytoskeleton and its role in motility 1 1
2.0 CHROMOSOMES 10  
2.1.1 Chromosome morphology 1 4
2.1.2 Fine structure, Dupraw model, Nucleosome model 1 4
2.1.3 Chemical organization of nucleosome – nucleoproteins 1 4
2..1.4 Types of chromosomes based on centromere, karyotype and idiogram 1 4
2.1.5 Special types of chromosomes – salivary gland, lampbrush and B chromosome. 1 4
2.2 Organization of genes and chromosomes    
2.2.1 Operon, interrupted genes, structure of chromatin and chromosomes, unique and repetitive DNA, heterochromatin, euchromatin, transposons    
2..2.2 Numerical aberrations of chromosomes -Aneuploidy and euploidy    
2..2.3 Structural aberrations of chromosomes: deletion, duplication, inversion and translocation and their Meiotic behaviour    
2.3 Mutations    
2.3.1 Spontaneous and induced. Mutagens – physical and chemical mutagens 1 5
2.3.2 Chromosomal and point mutation, Molecular mechanism of mutation: transition, transversion and substitution 1 5
3.0 CELL DIVISION AND CELL CYCLE    
3.1 Cell division and cell cycle: mitosis 1 6
3.2 Meiosis 1 6
3.3 Cell cycle regulation, steps and control of cell cycle 2 6
3.4 Stem cells – sources and applications 1 7
3.5 Cell -cell interactions, interactions of cells with their environment 2 8
3.6 Cell signaling 3 8
4.0 DEVELOPMENTAL BIOLOGY 22  
4.1 Introduction to developmental biology 4  
4..1.1 Basic concepts of development, potency, commitment, specification, induction, competence, determination and differentiation, genomic equivalence and cytoplasmic determinants: imprinting mutants and transgenics analysis of development. 2 9
4.2 Fertilization    
4.2.1 Gametogenesis, fertilization and early development 2 9
4.2.2 Animal development: oogenesis, fertilization, embryonic cleavage divisions: blastulation, gastrulation and morphogenesis 3 10
4.2.3 Development of model organisms- Drosophila, Caenorabitidis 2 10
4.2.4 Maternal and zygotic gene activity in development 1 10
4.3 Plant development    
4.3.1 Microsporogenesis 1 10
4.3.2 Megasporogenesis 1 10
4.3.3 Embryogenesis (brief only) 1 10
4.3.4 Establishment of symmetry in plants 1 10
4.3.5 Seed formation and development of seedling 2 10
4.3.6 Shoot and root meristem, leaf development 2 10
4.3.7 Development of model organism- neurospora, Arabidopsis 2 10

Text Books for Reference

1. Lodish et al.2004. Molecular Cell Biology “ (Scientific American Book)

2. Alberts et al. .2002. The Biology of the Cell

3. Cooper & Hausman .2004. The Cell – A Molecular Approach

4. Maheaswari, P. 1950. An introduction to embryology of Angiosperms. Mc Graw Hill.

5. Dodd, H.I., and Dodd, J.M. , 1978. The biology of metamorphosis , In Physiology of amphibia, Vol. 3, Academic press, N.Y

6. Gilbert, S.F., 1997. Developmental Biology, 5th Edn, Sinauer, Associates, Massachusettes.

7. Tamarin, R., 1991, Principles of Genetics, 3rd edition.

8. Vasudeva Rao, 1994. Developmental Biology: A modern synthesis, Oxford & IBH, New Delhi

9. De Robertis, E.D.P. and Robertis, E.M.F. 1991. Cell and molecular biology. Lea and Febiger

Text Books for Enrichment

1. Balinsky, B.I., 1965. An Introduction to embryology, W.B. Saunders company

2. Bodemer, L.W., 1968. Modern Embryology, Winston Inc. USA

3. George, M. Malacinski (ed) 1988, Developmental genetics of higher organisms, Macmillan Publishing Co.