Chemistry Faculty

Dr. Rony Rajan Paul

Assistant Professor

Education: BSc., MG University, 2005
MSc., MG Uiversity, 2007
PhD.,CSIR-NIST Thiruvananthapuram ,2013
Post-doc, University of Leuven, Belgium

Area of Specialization: Organic Synthesis, Organic methodology development

Email: rony@cmscollege.ac.in

Awards & Recognition:

Carl Benz Fellow- University of Duesseldorf, Germany 2009

Guest Scientist- University of Potsdam, Germany-2010

DST International Travel Grant- Netherlands, 2012

CSIR International Travel Grant-Italy, 2013

FLAIR International Intern-University of Nottingham, UK-2016

Other Details:

Conferences
Oral Presentations/Invited Talks
International Summer School, University of Milan, Italy
Tetraheron Symposum, Amsterdam, Netherlands
Young Researchers Meet, Georgia Tech, USA
Gilbert Stork Memorium, CSIR-NIIST

My research mainly focuses on the development of new methodologies in organic synthesis. The strategies which we mainly deal with includes multicomponent reactions, organocatalytic reactions as well as reactions involving single electron oxidants.

Multicomponent reactions are reactions in which more than two reactants combine in a sequential manner to give highly selective products that retain almost all the atoms of the starting materials. The atom economy and environmental benignity of the reactions makes it a versatile tool for the synthesis of compounds with more complexity. We will explore substrates that are hitherto unknown for this purpose and the synthetic strategy will be determined by theoretical studies which will be done by collaboration with a group in our department.
Organocatalysis has become a major field in organic chemistry addressing catalytic chemical transformations with nonmetallic molecules as precatalyst systems. Placed between the extremes of transition metal catalysis and enzymatic transformations, organocatalysis offers several advantages. In this area we will be mainly  investigating on N-heterocyclic carbenes as organocatalysts.

The explorations on the chemistry of single  electron oxidants involving the use of involve use of salts of high valent metals such as Mn(III), Ce(IV), Cu(II), Ag(I), Co(III), V(V), Fe(III), etc. will be a long standing goal in our research.

CH2C01 Basic Organic Chemistry

CH2CO1 Basic Organic Chemistry

AN4E03 Organic Reaction Mechanisms

1. A Facile Synthesis of Thiaaza- and Thiadiaza-fluorene Derivatives Involving Benzothiazole-DMAD Zwitterion with Arylidenemalononitriles and N-Tosylimines. Nair, V.; Devi, B. R.; Pillai, A. N.; Paul, R. R. Heterocycles. 2007, 73, 249.

2. Engaging Isoquinoline- Dimethyl Allenoate Zwitterion in Multicomponent Reactions: Facile Synthesis of   1H-Pyrido[2,1-a]isoquinoline Derivatives. Nair, V.; Beneesh P. B.; Varghese, V.; Sinu, C. R.; Paul, R. R.; Anabha, E. R; Suresh, E. Tetrahedron Lett. 2009, 50, 3716.

3. Reactions of Morita-Baylis-Hilman acetates with Huisgen Zwitterions-A novel strategy for the synthesis of ?-aminoacid derivatives. Jose, A.; Paul, R. R.; Mohan, R ; Mathew, S. C .; Biju, A.T.; Suresh, E.; Nair, V. Synthesis  2009, 1829.

4. Nucleophilic heterocyclic carbene as a novel catalyst for  cyclopropanation of  cyano acrylates. Anabha, E. R.; Paul, R.R.; Suresh, E. Nair, V. Org. Biomol. Chem. 2010, 8, 901.

5. NHC Catalyzed Transformation of Aromatic Aldehydes to Acids by Carbon Dioxide: An Unexpected Reaction. Nair, V.; Varghese, V.; Paul, R.R.; Jose, A.; Sinu, C.R.; Menon, R.S. Org. Lett. 2010, 12, 2653.

6. NHC-catalysed annulation of enals to tethered dienones: efficient synthesis of bicyclic dienes. Nair, V.; Vellalath, S.; Babu, B.P.;  Varghese, V.; Paul, R.R.; Suresh, E. Org. Biomol. Chem. 2010, 8, 4861.

7. Reaction of Diaryl-1,2-diones with Homophthalic Anhydride: Efficient Formation of Isobenzofuranone Derivatives . Nair, V.; Paul, R.R.; Suresh, E. Synthesis 2010, 3741.

8. Nitrone Cycloaddition to Quinones: A Novel Strategy for the Synthesis of Benzisoxazolidenes. Paul, R.R.; Varghese, V.; Beneesh, P.B.; Sinu, C. R.; Suresh, E.; Anabha, E. R. J. Heterocyclic. Chem. 2010, 47, 396.

9. N-Heterocyclic carbene (NHC) catalyzed annulation of enals and vinyl ketones:a novel synthesis of [2H]-pyranones. Nair, V.; Paul, R.R.; Lakshmi, K.C.S.; Menon, R.S.; Jose, A.; Sinu, C.R. Tetrahedron Lett. 2011, 52, 5992.

10. NHC-catalyzed annulation of enals and chalcones: further explorations on the novel synthesis of 1,3,4-trisubstituted cyclopentenes. Nair, V.; Paul, R.R.; Padmaja, D.V.M..; Aiswarya, N.;  Sinu, C.R.; Jose, A. Tetrahedron 2011, 67, 9885.

11. Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art. Nair, V.; Menon, R.S.; Biju, A.T.; Sinu,       C.R.; Paul, R.R.;   Jose, A.; Vellalath, S. Chem. Soc. Rev. 2011, 40, 5336.

12. A Facile Multicomponent Reaction Involving Isoquinoline, Dimethyl Allenedicarboxylate  and 2-Oxo- 1H-indol-3-ylidenes. Rajan, R.; Babu, B.P.; Kumar, A.; Paul, R.R.; Sinu, C.R.; Suresh, E. Synthesis  2012, 417.

13. Mercuric Triflate: Spotlight  Paul, R.R.  Synlett 2012, 23, 1997.

14. NHC-Catalysed Annulation of Enals to Ene-1,4-diones:Stereoselective Synthesis of 1,3-Diaryl-4-Acyl  Cyclopentenes. Paul, R.R.; Lakshmi, K.C.S.; Suresh, E.; Nair, V. Tetrahedron Lett. 2013, 54, 2046.

15. NHC-Mediated Homoenolate Annulation of Benzofuran-2,3-diones: Stereoselective Synthesis of Bis-Spirofuranones. Lakshmi, K.C.S.; Paul, R.R.; Suresh, E.; Nair, V. Synlett  2014, 25, 853.

16. 1,4-Dipolar cycloadditions and related chemistry. Nair, V.; Deepthi, A.; Ashok, D.; Anabha, E. R.; Paul, R.R. Tetrahedron 2014, 70, 3085.

17. Expedient Synthesis of Tricyclic Benzopyran-2-ones via N-Heterocyclic Carbene Catalyzed Annulation of Enals to ?-Methylene Cycloalkanones. Padmaja, D.V.M..; Sinu, C.R.; Krishnan, J. ; Paul, R.R.; Varghese. S; Lakshmi, K.C.S, Nair, V.; Tetrahedron 2015, 47, 9022.

18. Non-innocent probes in direct sonication: Metal assistance in oxidative radical C-H functionalization Demaerel, J.; Govaertes, S.; Paul, R.R.; De Borrgraeve, W.M. Ultrasonics Sonochemistry, 2018, 41, 134.

Book Chapter

Five Membered Carbocycles (Publishers: Wiley International)