Dr. Ajish K.R

Dr. Ajish K. R.

Assistant Professor
Email: ajish@cmscollege.ac.in

Education

  • BSc., MG University, 2003
  • MSc., MG University, 2006
  • B.Ed., MG University, 2007
  • Ph.D., CSIR-NIIST Thiruvananthapuram, 2015

Area of Specialization

  • Chemistry of Natural Products (Phytochemistry)
  • Synthetic Organic chemistry
  • Carbohydrate Chemistry
  • Best Paper Award at 24t h Swadeshi Science Congress (SSC-2014), Thunjath Ezhuthachan Malayalam University, Tirur, Malappuram, 2014.
  • Best Paper Award at National Conference on Recent Advances in Spectroscopy, M. A. College, Kothamangalam, 2014.
  • Best Paper Award at 23 rd Swadeshi Science Congress (SSC-2013), M. G. University, Kottayam, 2013.
  • Best Paper Award at International Seminar on “Molecular Secrets of Plant Medicines (MSPM 2013) CMS College, Kottayam, 2013.
  • Best Paper Award at National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013), University of Kerala, Kariavattom, 2013.
  • II nd rank, MSc Applied Chemistry, M.G. University, 2004-2006.
  • Best Oral Presentation Award by Royal Society of Chemistry (RSC) Cambridge at International Conference on Tropical Plants and Molecular Design, held at TKM College Kollam 2017
  • Phytochemical Analysis and Biological Evaluation of Rhizomes of Zingiber zerumbet Smith, Ajish K.R. and K.V. Radhkrishnan, International conference on Tropical Plants and Molecular Design, TKM College Kollam, 14 and 15 February 2017 [Best Paper Award by Royal Chemical Society]
  • Isolation, Synthetic Transformations and Biological Evaluation Of Zerumbone From Zingiber Zerumbet, Ajish K. R. And K. V. Radhakrishnan, “Prof. K V Thomas Endowment International Symposium on New Trends in Applied Chemistry (Ntac – 2017)” 09 – 11 February 2017

My major research areas are

  • Isolation, characterization and synthetic modifications of Phytochemical from various
  • medicinal plants found in Kerala and their biological evolution
  • Transition metal catalyst mediated synthesis of bioactive molecules
  • Design, synthesis and biological evaluation of glycohybrids
  • CH1CO1 Organometallics and Nuclear Chemistry
  • AP3C09 Advanced Synthetic Organic Chemistry
  • AP3C11 Essential Oils and Aromatics

Articles in Peer Reviewed Journals

  • Studies on ?-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith. K. R. Ajish, K. A. Antu, M. P. Riya, M. R. Preetharani, K. G. Raghu, B. P. Dhanya K. V. Radhakrishnan, Natural Product Research, 2015, 29, 947-952.
  • Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: A new class of ?-glucosidase inhibitors. K. R. Ajish, B.P. Dhanya, Nayana Joseph, M. Priya Rani, K. G. Raghu, V. P.Vineetha and K. V. Radhakrishnan. Tetrahedron lett. 2014, 55, 665-670.
  • Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with potent glycation and a-glucosidase inhibition activities. K. R. Ajish, Nayana Joseph, M. Priya Rani, K. G. Raghu, V. P. Vineetha, K. V. Radhakrishnan. Tetrahedron lett. 2013, 54, 5682-5685.
  • Transition-metal- catalyzed regio- and diastereoselective 1,4-conjugate addition of zerumbone using boronic acids: A simple route toward novel zerumbone derivatives. K. R. Ajish, Nayana Joseph, K. V. Radhakrishnan Synthesis 2013, 45, 2316-2322

Conferences

Oral presentations:

  • Synthesis and Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation and ?-Glucosidase Inhibition Activities, Ajish K. R. and K. V. Radhakrishnan,24 th Swadeshi Science Congress (SSC-2014), Thunchath Ezhuthachan Malayalam University, Malappuram, November, 2014 [Best Paper Award].
  • Isolation, Synthetic Transformation and Evaluation of Bioactives from Zingiber Zerumbet K.R. Ajish, K. V. Radhakrishnan. National Conference on Recent Advances in Spectroscopy, M. A. College, Kothamangalam, July 2014 [Best Paper Award].
  • Value addition to traditional knowledge: isolation, synthetic trasformation and evaluation of bioactives from zingiber zerumbet (malayinji). K.R. Ajish, K. V. Radhakrishnan. 26 th Kerala Science Congress, KVASU, Wayanad, January, 2014.
  • Synthesis of carbohydrate appended hydrazinocyclopentenes with potent glycation and ?-glucosidase inhibition activities. K. R. Ajish, M. Priya Rani, V. P. Vineetha, K. G. Raghu, K. V. Radhakrishnan. National Seminar on Current Trends in Chemistry (CTriC 2014), Department of Applied Chemistry, Cochin University of Science and Technology (CUSAT), January, 2014.
  • Isolation, synthetic trasformation and biological evaluation of phytochemicals from zingiber zerumbet smith (malayinji). K. R. Ajish, K.V. Radhakrishnan. 23 rd Swadeshi Science Congress (SSC-2013), M. G. University, Kottayam, November, 2013 [Best Paper Award].
  • Value Addition to herbal plants: Synthetic transformation & biological evaluation of phytochemical from Zingiber Zerumbet. K. R. Ajish, K.V. Radhakrishnan. International Seminar on Molecular Secrets of Plant Medicines (MSPM 2013) CMS College, Kottayam, October, 2013 [Best Paper Award].
  • Isolation, characterization and biological evaluation of phytochemicals from the rhizomes of Zingiber zerumbet Smith, Ajish K. R, M. Priya Rani, K. G. Raghu and K. V. Radhakrishnan, an oral presentation at National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013), held at University of Kerala, Kariavattom, may, 2013 [Best Paper Award].

Posters Presented:

  • Synthesis of novel zerumbone derivatives via transition metal catalyzed regio- and diastereoselective 1,4-conjugate addition using boronic acids. K. R. Ajish, K. V. Radhakrishnan. 9 th Junior National Organic Symposium Trust (J-NOST) Conference, IISER, Bhopal, December, 2013.
  • Transition metal catalyzed regio- and stereoselective 1,4-conjugate addition of boronic acids to zerumbone: A facile route towards novel zerumbone derivatives. K. R. Ajish, B. P. Dhanya, K. V. Radhakrishnan. National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013), University of Kerala, Kariavattom, May, 2013.
  • Design and Synthesis of carbohydrate appended hydrazino cyclopentenes with triazole linker: A new class of neoglycoconjugates with anti-glycation properties. K. R. Ajish, M. Priya Rani, K. G. Raghu, K. V. Radhakrishnan. National Seminar on Emerging Trends in Chemical Sciences (ETCS-2013), University of Kerala, Kariavattom, May, 2013.
  • An efficient strategy to functionalized cyclopentenes via palladium catalyzed ring opening of bicyclic hydrazines with catechol and resorcinol. K. R. Ajish, S. Saranya, K. Ramesh Babu, K. V. Radhakrishnan. International Symposium on Drug Development for Orphan/Neglected Diseases (CTDDR 2013), CDRI, Lucknow, February, 2013.
  • Efforts towards the Synthesis and Lanthanide Binding Studies of mannose Based Neoglycoconjugates. K. R. Ajish, V. S. Sajisha, K. V. Radhakrishnan. National Conference on Recent Trends in Organic Synthesis (RTOS 2011), Bharathidasan University, Tiruchirappalli, February, 2011.
  • ‘Basic Organic Chemistry’, Ajish K. R, Grace Publications, First Edition ISBN 9789284663811 December 2017

Chemistry
Department