Dr. Rony Rajan Paul

Assistant Professor
Email: [email protected]


  • BSc., MG University, 2005
  • MSc., MG University, 2007
  • PhD.,CSIR-NIST Thiruvananthapuram, 2013
  • Post-doc, University of Leuven, Belgium

Area of Specialization

  • Organic Synthesis
  • Organic methodology development
My research mainly focuses on the development of new methodologies in organic synthesis. The strategies which we mainly deal with includes multicomponent reactions, organocatalytic reactions as well as reactions involving single electron oxidants.

Multicomponent reactions are reactions in which more than two reactants combine in a sequential manner to give highly selective products that retain almost all the atoms of the starting materials. The atom economy and environmental benignity of the reactions makes it a versatile tool for the synthesis of compounds with more complexity. We will explore substrates that are hitherto unknown for this purpose and the synthetic strategy will be determined by theoretical studies which will be done by collaboration with a group in our department.
Organocatalysis has become a major field in organic chemistry addressing catalytic chemical transformations with nonmetallic molecules as precatalyst systems. Placed between the extremes of transition metal catalysis and enzymatic transformations, organocatalysis offers several advantages. In this area we will be mainly investigating on N-heterocyclic carbenes as organocatalysts.

The explorations on the chemistry of single electron oxidants involving the use of involve use of salts of high valent metals such as Mn(III), Ce(IV), Cu(II), Ag(I), Co(III), V(V), Fe(III), etc. will be a long standing goal in our research.

  • CH2C01 Basic Organic Chemistry
  • CH2CO1 Basic Organic Chemistry
  • AN4E03 Organic Reaction Mechanisms
  • New national and regional bryophyte records, 66
    LT Ellis, M Alataş, M Aleffi, WR lvaro Alba, DA Becerra Infante, …
    Journal of Bryology 43 (2), 193-212, 2021
  • Using Homoenolate Annulated Products for Synthesis of Indole Embedded Derivatives
    GS Athena, J Krishnan, E Suresh, RR Paul
    Asian Journal of Chemistry 33 (2), 319-324, 2021
  • Non-innocent probes in direct sonication: Metal assistance in oxidative radical CH functionalization
    J Demaerel, S Govaerts, RR Paul, T Van Gerven, WM De Borggraeve
    Ultrasonics sonochemistry 41, 134-142, 2018
  • Expedient synthesis of tricyclic benzopyran-2-ones via N-Heterocyclic carbene catalyzed annulation of enals to α-methylene cycloalkanones
    DVM Padmaja, CR Sinu, J Krishnan, RR Paul, S Varughese, …
    Tetrahedron 71 (47), 9022-9027, 2015
  • Five-Membered Carbocycles
    V Nair, RR Paul
    Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis…, 2015
  • N-Heterocyclic Carbene Mediated Homoenolate Annulation of Benzofuran-2, 3-diones: Stereoselective Synthesis of Bis-Spirofuranones
    KCS Lakshmi, RR Paul, E Suresh, V Nair
    Synlett 25 (06), 853-857, 2014
  • 1, 4-Dipolar cycloadditions and related reactions
    V Nair, A Deepthi, D Ashok, AE Raveendran, RR Paul
    Tetrahedron 19 (70), 3085-3105, 2014
  • NHC-catalysed annulation of enals to ene-1, 4-diones: stereoselective synthesis of 1, 3-diaryl-4-acyl cyclopentenes
    RR Paul, KCS Lakshmi, E Suresh, V Nair
    Tetrahedron Letters 54 (16), 2046-2049, 2013
  • Mercuric triflate
    RR Paul
    Synlett 23 (13), 1997-1998, 2012
  • A facile multicomponent reaction involving isoquinoline, dimethyl allenedicarboxylate, and 2-oxo-1H-indol-3-ylidenes
    R Rajan, BP Babu, A Kumar, RR Paul, CR Sinu, E Suresh, V Nair
    Synthesis 44 (03), 417-422, 2012
  • NHC-catalyzed annulation of enals and chalcones: further explorations on the novel synthesis of 1, 3, 4-trisubstituted cyclopentenes
    V Nair, RR Paul, DVM Padmaja, N Aiswarya, CR Sinu, A Jose
    Tetrahedron 67 (51), 9885-9889, 2011
  • N-Heterocyclic carbene (NHC) catalyzed annulation of enals and vinyl ketones: a novel synthesis of [2H]-pyranones
    V Nair, RR Paul, KCS Lakshmi, RS Menon, A Jose, CR Sinu
    Tetrahedron letters 52 (45), 5992-5994, 2011
  • Employing homoenolates generated by NHC catalysis in carbon-carbon bond-forming reactions: state of the art
    J Anu, V Sreekumar, AT Biju, RR Paul, CR Sinu, RS Menon
    Royal Society of Chemistry, 2011
  • Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art
    V Nair, RS Menon, AT Biju, CR Sinu, RR Paul, A Jose, V Sreekumar
    Chemical Society Reviews 40 (11), 5336-5346, 2011
  • Reaction of Diaryl-1, 2-diones with Homophthalic Anhydride: Efficient Formation of Isobenzofuranone Derivatives
    V Nair, RR Paul, E Suresh
    Synthesis 2010 (21), 3741-3744, 2010
  • NHC-Catalyzed Oxidation of Aromatic Aldehydes to Acids with CO2
    V Nair, V Varghese, RR Paul, A Jose, CR Sinu, RS Menon
    Synfacts 2010 (07), 0832-0832, 2010
  • NHC catalyzed transformation of aromatic aldehydes to acids by carbon dioxide: an unexpected reaction
    V Nair, V Varghese, RR Paul, A Jose, CR Sinu, RS Menon
    Organic letters 12 (11), 2653-2655, 2010
  • Nitrone cycloaddition to quinones: A novel strategy for the synthesis of benzisoxazolidenes
    RR Paul, V Varghese, PB Beneesh, CR Sinu, E Suresh, ER Anabha
    Journal of Heterocyclic Chemistry 47 (2), 396-399, 2010
  • NHC catalyzed transformation of aromatic aldehydes to acids by carbon dioxide: An unexpected reaction
    J Anu, RR Paul, CR Sinu, V Varghese, RS Menon
    American Chemical Society, 2010
  • NHC-catalysed annulation of enals to tethered dienones: efficient synthesis of bicyclic dienes
    V Nair, S Vellalath, BP Babu, V Varghese, RR Paul, E Suresh
    Organic & biomolecular chemistry 8 (21), 4861-4866, 2010
  • Nucleophilic heterocyclic carbene as a novel catalyst for cyclopropanation of cyano acrylates
    AE Raveendran, RR Paul, E Suresh, V Nair
    Organic & biomolecular chemistry 8 (4), 901-905, 2010
  • A novel multicomponent reaction involving isoquinoline, allenoate and cyanoacrylates
    V Nair, BP Babu, V Varghese, CR Sinu, RR Paul, ER Anabha, E Suresh
    Tetrahedron Letters 50 (26), 3716-3718, 2009
  • Reactions of Morita-Baylis-Hillman Acetates with Huisgen Zwitterions: A Novel Strategy for the Synthesis of β-Amino Acid Derivatives
    A Jose, RR Paul, R Mohan, SC Mathew, AT Biju, E Suresh, V Nair
    Synthesis 2009 (11), 1829-1833, 2009
  • Reactions of Morita–Baylis–Hillman Acetates with Huisgen Zwitterions: A Novel Strategy for the Synthesis of b-Amino Acid Derivatives
    J Anu, AT Biju, E Suresh, RR Paul, M Resmi, CM Smitha
    Thieme, 2009
  • A facile synthesis of thiaaza-and thiadiaza-fluorene derivatives involving benzothiazole-DMAD zwitterion with arylidenemalononitriles and N-tosylimines
    V Nair, R Devi B, AN Pillai
    Heterocycles 73, 249-254, 2007


  • Oral Presentations/Invited Talks
  • International Summer School, University of Milan, Italy
  • Tetraheron Symposum, Amsterdam, Netherlands
  • Young Researchers Meet, Georgia Tech, USA
  • Gilbert Stork Memorium, CSIR-NIIST