Dr. Jagadeesh K.

Assistant Professor
Email: [email protected]

Education

  • BSc., University of Calicut, 2010
  • MSc., Mahatma Gandhi University, 2012
  • PhD.,CSIR-NIIST Thiruvananthapuram, 2018
  • Post-doc, Indian Institute of Science Bangalore

Area of Specialization

  • Organic Chemistry
  • Medicinal Chemistry

My research focuses on the development of novel synthetic methodologies involving targeted synthesis for biological applications.

Our main research areas are:

  • Fluorine chemistry

Over the past 10 years, organofluorine compounds have attracted increasing attention primarily due to their widespread applicability in medicinal chemistry and related fields. My research focuses on the methodology development involving difluorocarbene and trifluoro carbanion generated from Ruppert-Prakash reagent (TMSCF3) and its derivatives TMSCF2Cl and TMSCF2Br for the construction of biologically relevant molecules for medicinal applications. Among the various fluorination techniques available, it offers a cost-effective and easy procedure opening avenues to a large number of organofluorine compounds with biological importance.

  • Tertiary amine catalysis

As one pillar of organic Lewis base catalysts, tertiary amine involved divergent nucleophilic catalysis has recently aroused considerable interest. In contrast to the well‐developed phosphine‐catalyzed cycloaddition reactions of electron‐deficient alkenes, allenoates, and MBHADs, nucleophilic amine-catalyzed cycloadditions have been studied far less. Compared to phosphine catalysis, the zwitterionic intermediates generated from organoamine display markedly different reaction profiles in these types of reactions, which could be attributed to their subtle difference in intrinsic properties such as the stabilizing ability of intermediates. This subtle difference opens up greater opportunities for the development of new reaction scenarios.

  • Catalysis using clay-based metal Nanohybrids

The development of efficient methods that minimize environmental problems is a great challenge for chemists in both industrial and academic research. Our interest is in the development of clay-based Nanocatalysts for the catalysis of important organic reactions such as selective oxidations and reductions, cross-coupling reactions, etc. In this context, we will design and synthesize new, green, and reusable, clay-based metal nanohybrid for the catalysis of a wide variety of organic reactions.

  • CH1922601 : Inorganic Chemistry Practical – I
  • CH1814204 : ADVANCED BIO ORGANIC CHEMISTRY
  • CH1816110 : ORGANIC CHEMISTRY – IV
  • AC1923110 : Advanced Synthetic Organic Chemistry
  • CH1811201 : Basic Theoretical and Analytical Chemistry
  • AC1924303 : Advanced Applied Chemistry

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  • ‘A short and cost-effective synthetic route towards anti-viral EIDD-1931 and its hydrate polymorphs’ Jubi John, Sunil Varughese, K. V. Radhakrishnan, A. Ajayaghosh, Jagadeesh Krishnan, Divya I. S., Abhijith B., Akhil K. R., Priya S., (Submitted to IPO, Application No. 202111047808, dated: 20/10/2021).

  • Efficient Synthesis of Tricyclic Benzopyran-2-ones and Tricyclic Cyclopentenes via N-Heterocyclic Carbene Catalyzed Homoenolate Annulation. Jagadeesh Krishnan; Vijay Nair.International Conference on Nascent Developments in Chemical Sciences; BITS Pilani,Rajastan, October-2015, Poster # 082 (Won the best poster award Sponsored by IndianSociety of Chemists & Biologists (ISCB), Lucknow).
  • N-Heterocyclic Carbene Catalyzed Homoenolate Annulation of α-methylene cycloalkanonesand Chroman-3-ene-4-ones for the synthesis of Tricyclic Benzopyran-2-ones and TricyclicCyclopentenes. Jagadeesh Krishnan; Vijay Nair. CTDDR-2016, CSIR-CDRI, Lucknow,Uttarpradesh February 2016, Poster # 172.
  • Sequential NHC-Catalyzed Reaction of Enals and Cyclic Aryldiene-1,3-diones:Synthesis ofTricyclic Chromenones and Related Compounds. Jagadeesh Krishnan. Prof. R. HSahasrabudhey Birth Centenary Symposium (CYHOC-2017), Thiruvananthapuram, December2017, Oral Presentation.
  • N-Heterocyclic Carbene as a versatile tool for Organocatalysis and MCR. JagadeeshKrishnan, Vijay Nair. 22nd CRSI National Symposium in Chemistry, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, February 2018, Poster #32.
  • An Uncommon Multicomponent Reaction Involving Nuclephilic Heterocyclic Carbebenes:Facile Synthesis of fully substituted cyclopentanones. JagadeeshKrisnan. 30th Kerala Science Congress, Govt. Brennen College, Thalassery, January 2018, Oral Presentation # 03-11.

Expanding the Utility of Rhodium-Iminocarbene in Natural Products, DST-SERB, SURE project, 2023-26  Co-PI

  • Awarded consolation prize in phase-I of Drug Discovery Hackathon 2020 conducted byGovernment of India.
  • Won the best poster award sponsored by Indian Society of Chemists & Biologists (ISCB),Lucknow for International Conference on Nascent Developments in Chemical Sciences; BITSPilani, Rajastan, October-2015.
  • Senior Research Fellowship (SRF) University Grants Commission, India, 2016 August.
  • Junior Research Fellowship (JRF) and National Eligibility Test (NET) for College Lecturer, University Grants Commission, India, 2013 December.
  • Selected for KSCSTE research fellowship 2013 awarded by Kerala State Council for Science Technology and Environment.
  • Qualified GATE, Chemistry

Chemistry
Department